Gene
appb
- ID
- ZDB-GENE-020220-1
- Name
- amyloid beta (A4) precursor protein b
- Symbol
- appb Nomenclature History
- Previous Names
-
- wu:fc43a03 (1)
- zgc:92771
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activator activity and signaling receptor binding activity. Acts upstream of or within several processes, including nervous system development; regulation of Notch signaling pathway; and regulation of non-motile cilium assembly. Predicted to be located in Golgi-associated vesicle and membrane. Predicted to be active in several cellular components, including Golgi apparatus; early endosome; and membrane raft. Is expressed in several structures, including axial vasculature; axis; nervous system; pronephric duct; and spinal cord neural rod. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and traumatic brain injury. Orthologous to human APP (amyloid beta precursor protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92771 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 27 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb764 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| ihb765 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| la016566Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029590Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mde31 | Allele with one deletion | Exon 1 | Premature Stop | CRISPR | |
| sa327 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34693 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41475 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| u537 | Allele with one delins | Exon 1 | Unknown | TALEN | |
| zf3355 | Allele with one delins | Exon 2 | Unknown | CRISPR |
1 - 10 of 11
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-appb | (3) | |
| CRISPR2-appb | Zebrafish Nomenclature Committee | |
| CRISPR3-appb | Rahmati et al., 2024 | |
| CRISPR4-appb | Rahmati et al., 2024 | |
| CRISPR5-appb | Zebrafish Nomenclature Committee | |
| MO1-appb | N/A | (3) |
| MO2-appb | N/A | (3) |
| MO3-appb | N/A | Song et al., 2012 |
| MO4-appb | N/A | Kaiser et al., 2012 |
| MO5-appb | N/A | (3) |
1 - 10 of 11
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Alzheimer's disease 1 | Alliance | Alzheimer disease 1, familial | 104300 |
| APP-related cerebral amyloid angiopathy | Alliance | Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic variants | 605714 |
1 - 2 of 2
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019744 | Amyloidogenic glycoprotein, copper-binding domain conserved site |
| Conserved_site | IPR019745 | Amyloidogenic glycoprotein, intracellular domain, conserved site |
| Conserved_site | IPR020901 | Proteinase inhibitor I2, Kunitz, conserved site |
| Domain | IPR002223 | Pancreatic trypsin inhibitor Kunitz domain |
| Domain | IPR008154 | Amyloidogenic glycoprotein, extracellular |
1 - 5 of 16 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Amyloidogenic glycoprotein | Amyloidogenic glycoprotein, amyloid-beta peptide | Amyloidogenic glycoprotein, copper-binding | Amyloidogenic glycoprotein, copper-binding domain conserved site | Amyloidogenic glycoprotein, copper-binding domain superfamily | Amyloidogenic glycoprotein, E2 domain | Amyloidogenic glycoprotein, extracellular | Amyloidogenic glycoprotein, heparin-binding | Amyloidogenic glycoprotein, heparin-binding domain superfamily | Amyloidogenic glycoprotein, intracellular domain, conserved site | Beta-amyloid precursor protein C-terminal | E2 domain superfamily | Pancreatic trypsin inhibitor Kunitz domain | Pancreatic trypsin inhibitor Kunitz domain superfamily | PH-like domain superfamily | Proteinase inhibitor I2, Kunitz, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q8UUR9 | InterPro | 694 | ||||||||||||||||
| UniProtKB:A0A8M1PBL6 | InterPro | 694 | ||||||||||||||||
| UniProtKB:A0AB32TZZ9 | InterPro | 733 | ||||||||||||||||
| UniProtKB:B0V0E5 | InterPro PDB | 751 |
1 - 4 of 4
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1BAC(appb:EGFP) |
|
| 1 | (3) | |
| Tg2BAC(appb:EGFP) |
|
| 1 | (3) | |
| Tg3BAC(appb:EGFP) |
|
| 2 | (3) | |
| Tg4BAC(appb:EGFP) |
|
| 1 | (3) | |
| Tg(appb:EGFP) |
|
| 1 | (4) |
1 - 5 of 5
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-192G7 | ZFIN Curated Data | |
| Encodes | EST | fc43a03 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92771 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152886 (1) | 4099 nt | ||
| Genomic | GenBank:BX294188 (1) | 261943 nt | ||
| Polypeptide | UniProtKB:B0V0E5 (1) | 751 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Özcan, G.G., Lim, S., Canning, T., Tirathdas, L., Donnelly, J., Kundu, T., Rihel, J. (2024) Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance. iScience. 27:108870108870
- Rahmati, M., Chebli, J., Banote, R.K., Roselli, S., Agholme, L., Zetterberg, H., Abramsson, A. (2024) Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay. eNeuro. 11(6):
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Park, J., Kim, D.Y., Hwang, G.S., Han, I.O. (2023) Repeated sleep deprivation decreases the flux into hexosamine biosynthetic pathway/O-GlcNAc cycling and aggravates Alzheimer's disease neuropathology in adult zebrafish. Journal of neuroinflammation. 20:257257
- Wei, J., Wang, X., Dong, Y., Zhong, X., Ren, X., Song, R., Ma, J., Yu, A., Fan, Q., Yao, J., Shan, D., Lv, F., Zheng, Y., Deng, Q., Li, X., He, Y., Fan, S., Zhao, C., Wang, X., Yuan, R., She, G. (2022) Curcumae Rhizoma - combined with Sparganii Rhizoma in the treatment of liver cancer: Chemical analysis using UPLC-LTQ-Orbitrap MSn, network analysis, and experimental assessment. Frontiers in pharmacology. 13:10276871027687
- Capriello, T., Monteiro, S.M., Félix, L.M., Donizetti, A., Aliperti, V., Ferrandino, I. (2021) Apoptosis, oxidative stress and genotoxicity in developing zebrafish after aluminium exposure. Aquatic toxicology (Amsterdam, Netherlands). 236:105872
- Chebli, J., Rahmati, M., Lashley, T., Edeman, B., Oldfors, A., Zetterberg, H., Abramsson, A. (2021) The localization of amyloid precursor protein to ependymal cilia in vertebrates and its role in ciliogenesis and brain development in zebrafish. Scientific Reports. 11:19115
- Karuppan, S.J., Vogt, A., Fischer, Z., Ladutska, A., Swiastyn, J., McGraw, H.F., Bouyain, S. (2021) Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface. The Journal of biological chemistry. 298(2):101541
- Banote, R.K., Chebli, J., Şatır, T.M., Varshney, G.K., Camacho, R., Ledin, J., Burgess, S.M., Abramsson, A., Zetterberg, H. (2020) Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish. Scientific Reports. 10:10127
1 - 10 of 45
Show